Age-related decline in brain resources magnifies genetic effects on cognitive functioning
نویسندگان
چکیده
منابع مشابه
Age-Related Decline in Brain Resources Modulates Genetic Effects on Cognitive Functioning
Individual differences in cognitive performance increase from early to late adulthood, likely reflecting influences of a multitude of factors. We hypothesize that losses in neurochemical and anatomical brain resources in normal aging modulate the effects of common genetic variations on cognitive functioning. Our hypothesis is based on the assumption that the function relating brain resources to...
متن کاملGenetic Biomarkers on Age-Related Cognitive Decline
With ever-increasing elder populations, age-related cognitive decline, which is characterized as a gradual decline in cognitive capacity in the aging process, has turned out to be a mammoth public health concern. Since genetic information has become increasingly important to explore the biological mechanisms of cognitive decline, the search for genetic biomarkers of cognitive aging has received...
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OBJECTIVE To identify genetic risk factors associated with susceptibility to age-related cognitive decline in African Americans (AAs). METHODS We performed a genome-wide association study (GWAS) and an admixture-mapping scan in 3,964 older AAs from 5 longitudinal cohorts; for each participant, we calculated a slope of an individual's global cognitive change from neuropsychological evaluations...
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Critical requirements for the hypothesis that executive functioning is a potential mediator of age-related effects on cognitive functioning are that variables assumed to reflect executive functioning represent a distinct construct and that age-related effects on other types of cognitive functioning are reduced when measures of executive functioning are statistically controlled. These issues wer...
متن کاملNeuroanatomical substrates of age-related cognitive decline.
There are many reports of relations between age and cognitive variables and of relations between age and variables representing different aspects of brain structure and a few reports of relations between brain structure variables and cognitive variables. These findings have sometimes led to inferences that the age-related brain changes cause the age-related cognitive changes. Although this conc...
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ژورنال
عنوان ژورنال: frontiers in Neuroscience
سال: 2008
ISSN: 1662-4548
DOI: 10.3389/neuro.01.039.2008